| Meno: | Askar
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| Priezvisko: | Gafurov
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| Názov: | Probabilistic Models for Genome Assembly with Chromatin Interaction Frequencies
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| Vedúci: | doc. Mgr. Bronislava Brejová, PhD.
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| Rok: | 2018
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| Blok: | INF
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| Kµúčové slová: | Genome assembly, maximum likelihood, probabilistic modeling, Hi-C, chromatin interaction frequencies, GAML
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| Abstrakt: | In this paper we have addressed the task of genome assembly using the data of chro-
matin interactions (Hi-C). Inspired by the work of Kaplan and Dekker [1], we have
proposed our own probabilistic model for Hi-C data, suited specifically for the GAML
framework for genome assembly [2]. As the original GAML implementation was a
prototype not meant to be extended, we have reimplemented most of its features in
the second implementation, called GAML2, and then added our model and algorithms
to process Hi-C data. We have shown that our implementation of GAML is able to
perform better with Hi-C data available.
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